A number of matches throughout the nation have already been affected by the virus this season.
UEFA has announced Inter and Ludogorets will meet behind closed doors at San Siro in the next leg of the Europa League tie on Thursday.
The decision was taken by the governing body because of concerns over the coronavirus outbreak in Italy. Two people have died in the nation while reports say dozens more have tested positive.
Bulgarian champions Ludogorets had demanded assurances that it was safe to go to Milan in a statement published on Sunday, calling on UEFA to provide swift clarification.
Inter, who won the first meeting 2-0 thanks to goals from Christian Eriksen and Romelu Lukaku, will point the return fixture with no fans present inside the famed venue.
“Earlier in the afternoon, the Milan club sent a letter to Ludogorets, announcing that the city’s health authorities allowed the game to be held with lovers,” a statement on Ludogorets’ site to read.
“The European headquarters advises Ludogorets it will demand the conclusion of the Milan medical authorities. UEFA also announces it is monitoring the situation in Northern Italy and will respond immediately if changed.
It had been confirmed by Inter in a statement on Monday that no spectators will be present for the experience.
Inter’s clash with Sampdoria was among four Serie A fittings to be postponed on Sunday, while there are doubts over whether their forthcoming visit to Juventus will go ahead.
Atalanta vs Sassuolo, Torino vs Parma and Verona vs Cagliari were also cancelled amid the worries.
According to Italian news agency ANSA, 88 amateur soccer games scheduled to take place in Lombardy last Saturday was postponed, while Serie C and Serie D matches were also impacted.
Italy prime minister Giuseppe Conte has said each the top-tier Italian matches, including the blockbuster showdown in Turin, might be called off because of this virus, which originated in China.
There have been 152 reported cases in the nation, and quarantine restrictions are put in place in the Veneto and Lombardy regions.
Many lives, schools, events, and businesses are affected by the outbreak, and approximately 50,000 people are stuck where they are for at least two weeks.